Intestinal worms infect over 2 billion people across the world, mostly children, in areas with poor sanitation. Nicola Harris at Ecole Polytechnique Federale de Lausanne in Switzerland has now shown that the anti-inflammatory activity of intestinal helminths involves "cross-talk" with an unexpected agent: the gut’s bacteria, also known as the "microbiome. But despite causing serious health problems, worms can actually help the immune system of its host as an indirect way of protecting themselves, researchers said. The receptors are also known to contribute to certain functions - and malfunctions - of the colon, and are even involved in modulating allergic https://www.reducerfactory.net/product/wp-worm-gear-reducers/ airway disease. For example, helminths can ameliorate diseases such as allergic asthma. Like the pigs, the mice showed an increased production of short-chain fatty acids. Because of their long co-evolution with mammals, helminths have developed a close relationship with their host’s immune systems, to the point that they can regulate the host’s immune system in beneficial ways.Intestinal worms infect over 2 billion people across the world London: Researchers have discovered how intestinal worm infections cross-talk with gut bacteria to help boost the immune system. The work highlights the microbiome as a new pathway through which helminths could influence the immune function of the host. The work is published in the journal Immunity. After chronic infection with the helminths, they discovered that the animals’ metabolism had been changed drastically; specifically, they produced increased levels of a class of fats in the gut called "short-chain fatty acids. Intestinal worms belong to a larger family of helminths, which are large multicellular parasites that can cause chronic infections in their hosts. Further testing showed that these acted on the same receptors to influence specific immune cells." In this study, the researchers looked at the effects of helminths that infect pigs. In short, the researchers uncovered a clear link between worm infection, microbiome, and the immune system.. However, very little is known about how helminths modulate the immune system. This is exactly what the researchers found when they also monitored cells in the immune system of mice that had been infected with a helminth." These fatty acids are produced by the microbiome, and can activate a family of receptors that in turn influence the immune system

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